| Number | In Season | Title | Original Air Date | Production code |
|---|---|---|---|---|
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Cartman's Silly Hate Crime 2000 | |||
| Cartman is pursued by the FBI for committing a hate crime and lands in juvenile hall. | Apr 12, 2000 | 49 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | The Tooth Fairy's Tats 2000 | |||
| When Cartman discovers the Tooth Fairy is paying a premium price for his lost teeth, he and the boys seize the opportunity to make some cash. | Apr 5, 2000 | 50 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Quintuplets 2000 | |||
| 8-year-old contorting quintuplets from Romania defect to the United States and seek shelter with Stan's family. | Apr 26, 2000 | 51 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Timmy 2000 | |||
| When Timmy is diagnosed with Attention Deficit Disorder, it triggers a wave of prescription drug abuse at South Park Elementary. | Apr 19, 2000 | 52 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Pip | |||
| When Pip is offered the opportunity to become a gentleman he goes to London only to discover that Miss Havisham plans to break his heart. | Nov 29, 2000 | 53 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Cartman Joins NAMBLA | |||
| Cartman decides to seek friendship using the Internet, and finds an older man who is more than willing to be his friend...and more. | Jun 21, 2000 | 54 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Cherokee Hair Tampons | |||
| Kyle needs a kidney transplant and Cartman is a discovered to be the perfect donor. Cartman gladly offers his kidney to Kyle -- for the price of $10 million dollars. | Jun 28, 2000 | 55 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Chef Goes Nanners | |||
| Chef's passionate protest declaring the South Park flag racist enflames the entire town. | Jul 5, 2000 | 56 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Something You Can Do With Your Finger | |||
| "Fingerbang" is the newest boy band starring all the boys and it's also Cartman's latest scheme to make a million dollars. | Jul 12, 2000 | 57 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Do the Handicapped Go to Hell? | |||
| The boys learn in Sunday school that they must confess their sins, but worry about Timmy since all he can say is his own name. | Jul 19, 2000 | 58 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Probably | |||
| Cartman's flock begins to grow and the children begin plans to build him a Church. Meanwhile, Satan turns to God for advice. | Jul 26, 2000 | 59 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Fourth Grade | |||
| The boys devise a plan to travel back in time a full year and return to the third grade, with the help of Timmy and his electronic wheelchair. | Nov 8, 2000 | 60 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Trapper Keeper | |||
| When he finally stops bragging about his new Trapper Keeper, a stranger informs him that it will eventually take over the world and destroy humankind, if they don't destroy it first. | Nov 15, 2000 | 61 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Helen Keller! The Musical | |||
| When Butters informs the forth grader's that the Kindergarteners school play is a magnificent sight to behold, they go through a lot of pain to make sure they beat the tiny tots' show. | Nov 22, 2000 | 62 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | Fat Camp | |||
| Cartman's family and friends have intervened and are forcing him to trim down. While Cartman's away, Kenny's star is on the rise when he gets his own reality TV show. | Dec 6, 2000 | 63 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | The Wacky Molestation Adventure | |||
| To get back at his parents for not letting him go to a concert, Kyle tells the police that his parents molested him. Soon, the whole town is free of adults and divided into two rival cities | Dec 13, 2000 | 64 | ||
| http://southparkstudios.mtvnimages.com/images/south_park/episode_thumbnails/s{{{S}}}e{{{E}}}_480.jpg | A Very Crappy Christmas | |||
| When Mr. Hankey skips Christmas, the boys find him living with his alcoholic wife and their three little nuggets. He tells them that no one is into Christmas anymore | Dec 20, 2000 | 65 | ||
